Early developmental characterization of gap-induced prepulse inhibition and habituation of auditory startle response in a Fragile X Syndrome mouse model.

Altered stimulus-specific adaptation at the auditory cortex of a mouse model of Fragile X Syndrome

Hyperexcitability in hippocampal CA1 pyramidal cells OF Fmr1 knockout mice emerges during late postnatal development.

It is concluded that CA1 PCs hyperexcitability from Frm1 KO mice was detectable at late postnatal development (P21-28), but not earlier (P8-15), and was due to a shifting of action potential voltage threshold to more hyperpolarized values.

Midbrain Glutamatergic Neurons Modulate the Acoustic Startle Reflex and Prepulse Inhibition in Mice.

Prepulse inhibition (PPI) of the acoustic startle reflex is a widely used operational measure of sensorimotor gating that is disrupted in several neuropsychiatric disorders. PPI deficits are a hallmark feature of schizophrenia, often associated with attentional and cognitive impairments. Although PPI is extensively use...

ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome

A causal link from FMRP loss to circuit dysfunction and ERK pathway dysregulation is established, and it is suggested that targeting this pathway may offer a promising strategy for treating social dysfunction in ASD and FXS.

Cntnap2 deletion in mice causes developmentally transient alterations in auditory processing and persistent startle hyperreactivity

It is shown that early auditory dysfunction is a conserved consequence of Cntnap2 loss early in development but normalized in adulthood, similar to the Cntnap2 knockout rat model, and reinforces the need to consider sex as a biological variable when investigating neural mechanisms underlying neurodevelopmental disorder...

Novel Co-expression of Group I Metabotropic Glutamate Receptor During Mouse Cochlear Nucleus Development

Metabotropic glutamate receptors (mGluR) are G-protein coupled receptors that regulate neuroplasticity and have been shown to play a role in auditory processing. However, not much is known about the expression of mGluRs during cochlear nucleus development in the context of Fragile X syndrome (FXS). FXS is the most comm...