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Genomic landscape of rare variants in a Chinese autism cohort and discovery of novel risk genes.

Senwei Tan Yongqing Lyu Xiaoyue Sun Ruolan Guo Xiaolei Zhang Z. Song Kewen Chen Chenzhang Li Yi Zheng Canhui Jiang Cai Qin Ting Bai Guizhi Tang Juan Li Zhigao Long Q. Pan Jieqiong Tan Ningxia Zhao Y. Hao Yu Zhang Yidong Shen J. Ou Yonghua Cui Chanjuan Hao Xiangbin Jia Lu Xia Jinchen Li Zhengmao Hu Wei Li Hui Guo Kun Xia
Jul 2026 · Molecular Psychiatry · 1 citation · 90 references
Medicine

TL;DR

A whole-genome sequencing analysis of 3109 samples across 1033 Chinese ASD families expands the ASD genetic landscape and suggest convergent pathogenic axes involving transcriptional regulation, synaptic signaling and plasticity, and neuroimmune interactions.

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