TL;DR
Hordenine emerges as a promising natural scaffold for developing carbonic anhydrase inhibitors with additional antioxidant properties, whereas alpinetin provides complementary radical scavenging activity.
It is demonstrated that azo-chalcone hybrids constitute a promising scaffold for the development of potent carbonic anhydrase inhibitors, with compound 1 identified as a strong candidate for further optimization and preclinical investigation.
These integrated experimental and computational results demonstrate that the polyhydroquinoline scaffold represents a promising platform for developing next-generation antidiabetic therapeutics with enhanced efficacy and favorable safety profiles.
Assessment of the anti-PPO activity of protocatechualdehyde (PCA) offers some valuable insights into the development of PPO inhibitor and anti-browning agent, and provides a theoretical foundation for the potential application of PCA in the area of food preservation.
Structural-activity relationship analysis indicated that the electron-withdrawing substituents at the para-position of aryl ring, together with nitrogen-containing heteroaromatic moieties, improve both binding affinity and free radical scavenging activity.
These findings highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation, and highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation.
To obtain molecules with dual activities of antioxidant effect and tyrosinase inhibition, a new series of Trolox derivatives (5a-5g) were constructed by incorporating thiosemicarbazone moieties into Trolox based on the molecular hybridization principle. In vitro antioxidant and tyrosinase inhibition assays showed that...
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