Sep 2026· Colloids and Surfaces B: Biointerfaces· Vol 269, pp.
116146
· 0 citations· 58 references
Medicine
Abstract
Conventional prochloraz (Pro) formulations suffer from poor stability, inadequate leaf deposition, and short persistence. In this work, we developed GA-Pro nanoparticles via ultrasound-assisted self-assembly of glycyrrhizic acid (GA), a natural amphiphile, and Pro. The 125.3 nm spherical nanoparticles, stabilized by hydrogen bonding, electrostatic, and van der Waals interactions, exhibited acid-responsive release (84.34% at pH 3.0 over 5 days) and enhanced photostability. GA-Pro significantly improved leaf interfacial performance, reducing surface tension to 46.1 mN/m, decreasing contact angle to 73.58 ° within 60 s, and increasing post-rain retention to 1.39-fold that of Pro EW. In vitro and in vivo assays demonstrated superior antifungal activity (EC50= 0.24 μg/mL) and 96.55% control efficacy, with metabolomics revealing enrichment of metabolic pathways associated with plant defense responses. Biosafety assessments confirmed low hemolysis, high cell viability, and no phytotoxicity. Overall, GA-Pro provides a promising biosafe, acid-responsive nanoplatform for tomato gray mold management.
Lauric acid (LA) is an antimicrobial medium-chain fatty acid, but its poor aqueous solubility limits its application in food matrices. To address this, ultrasound-assisted emulsion was developed using LA in vitamin E (VE) oil and chitosan-polyvinyl alcohol (CS-PVA) aqueous matrix. The emulsion exhibited uniformly dispe...
Chen Li, Pei-Pei Ma, Xiao-Yue Sui et al.· Food Research International· 0 citations
Low-molecular-weight hydrogels (LMWHs) show promise for bioactive delivery but are limited in food systems by high gelation thresholds and poor incorporation of hydrophobic compounds. Here, a food-grade supramolecular hydrogel based on glycyrrhizic acid (GA) was developed, in which a marine-derived natural product, dia...
Conventional pesticide formulations suffer from poor targeting and low active ingredient utilization due to their inability to respond to microenvironmental signals at pest feeding sites. Here, we developed pH-responsive nanogels by crosslinking chitosan with PLP via Schiff base formation and electrostatic interactions...
Ping Liang, Bing-Ke Li, Guo-Rui Liu et al.· International Journal of Bio...· 0 citations
The conventional agrochemicals suffer from intrinsic drawbacks including high volatility, rapid photodegradation, and poor interfacial retention, which severely compromise their efficacy and raise environmental risks. Herein, we report a stoichiometry‐driven, one‐pot supramolecular assembly strategy to construct py...
Massive pesticide loss during field application leads to severe environmental contamination and low utilization efficiency, while existing mitigation strategies are often operationally complex or limited to a single spraying stage. In this work, a nonionic hyperbranched surfactant was rationally designed to simultaneou...
Polydopamine-functionalized sodium alginate nanoparticles (SA-PDAs) were fabricated through self-assembly of dopamine-modified sodium alginate with cetyltrimethylammonium bromide and Tween 80, followed by in situ oxidative polymerization. The nanoparticle served as an excellent carrier for the controlled release of ema...
Xiao-Qiu Wen, He-Lin Wang, Sheng-Qian Wu et al.· Journal of Agricultural and...· 0 citations
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