TL;DR
The Cu(II)-flavonoid combination demonstrates significant anti-proliferative, pro-apoptotic, and anti-metastatic properties in colorectal cancer cells, while exhibiting lower cytotoxic effects in normal colon cells.
Findings indicate that bioactive compounds from A. biennis can suppress colorectal cancer cell growth through apoptosis induction and consistent with inhibition of migration-related behavior, highlighting their potential for further investigation as anticancer agents.
Collectively, emodin suppresses CRCSC characteristics in vitro by downregulating Wnt/β-catenin signaling and inducing AIF-associated caspase-independent apoptosis, highlighting its therapeutic potential against CRC.
Research in the area of hallmarks of cancer has opened the possibility of designing novel therapeutic interventions based on modulating cancer properties. Interestingly, the epithelial-mesenchymal transition (EMT), important in both tumour growth and metastasis, has not been targeted in prostate cancer (PCa). Previousl...
The c-Myc protein is a key regulator of cell growth, proliferation, and differentiation. Its overexpression or dysregulation is linked to several cancers, including non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). Here, we described ECD, a novel small molecule targeting c-Myc, which disrupts the c-Myc/MA...
GNE-3511 exerts potent anticancer activity by disrupting CDK7/9-dependent transcriptional programs that regulate proliferation, apoptosis, stemness, EMT, and multidrug resistance and is identified as a potential lead candidate for the treatment of colorectal cancers.
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