of ethyl vanillin against A β ‑induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis

Antioxidant efficacy of N-acetylcysteine against acrylamide-induced toxicity in Leydig cells by modulating p53/Bax/Caspase-3 pathway.

Acrylamide (Acr) is a widely encountered environmental and dietary toxicant known to induce oxidative stress and disrupt male reproductive function. Leydig cells, due to their high metabolic activity and mitochondrial dependence, are particularly vulnerable to redox imbalance. N-acetylcysteine (Nac), a thiol-containing...

Recombinant Annexin A5 Alleviates Aluminum Chloride-Induced Cytotoxicity, Mitochondrial Dysfunction, and Apoptotic Signaling in SH-SY5Y Cells

Background: Aluminum contributes to neurodegeneration by inducing oxidative stress, disrupting mitochondrial membrane potential (MMP), and triggering apoptotic signaling cascades. Annexin A5 (ANXA5) is implicated in membrane repair, ion transport regulation, and neuroprotection. This study aimed to evaluate whether ANX...

Protective Role of Curcumin on Apoptosis Levels in Sodium Azide-Induced Stress Model in SH-SY5Y Cells

Oxidative stress, impairments of cellular ATP production and changes in membrane integrity of mitochondria are components of mitochondrial dysfunction and are cross borders of several neurodegenerative diseases. Sodium azide is a chemical agent targeting mitochondrial oxidative phosphorylation and widely used in experi...

pancreatic β cell damage by morin: Involvement of the AMPK‑FOXO3‑catalase signaling pathway

The potential of astaxanthin in reducing lithium-induced neuroinflammation: Inhibitory effects on the NF-κB pathway.

BACKGROUND Lithium (LIT) can induce neurotoxicity through multiple mechanisms, including oxidative stress, neuroinflammation, and dysregulation of neuronal survival and cell death pathways. Astaxanthin (AST) is a xanthophyll carotenoid with potent antioxidant and anti-inflammatory properties and can scavenge reactive o...

Ginkgolide B Attenuates 6-Hydroxydopamine-Induced Cellular Damage and Modulates Oxidant-Evoked Ca2+ Signalling in SH-SY5Y Cells

Oxidative stress and disruption of intracellular Ca2+ homeostasis contributes to dopaminergic neuronal damage in Parkinson’s disease. In this study, the protective effects of Ginkgolide B (GKB) against 6-hydroxydopamine (6-OHDA)-induced SH-SY5Y cell damage were investigated, with particular attention to oxidant-evoked...