This report underscores the diagnostic difficulty, rapid deterioration and high mortality risk when HLH coexists with opportunistic infections when HLH coexists with opportunistic infections.
Abstract
A 19-year-old male presented with secondary hemophagocytic lymphohistiocytosis, persistent fever, abdominal pain and melaena. His clinical course was complicated by gram-negative sepsis (Klebsiella NDM-positive and E coli), Clostridioides difficile infection, cytomegalovirus (CMV) pneumonia and Elizabethkingia anophelis infection, leading to multiorgan dysfunction syndrome and massive gastrointestinal bleeding. Diagnosis was confirmed via bone marrow biopsy and relevant imaging. Management included HLH-2004 immunochemotherapy, broad-spectrum antimicrobials, ICU support and blood transfusions. This report underscores the diagnostic difficulty, rapid deterioration and high mortality risk when HLH coexists with opportunistic infections.
Gastrointestinal mucormycosis is a rare but life-threatening invasive fungal infection affecting immunocompromised individuals. Emphysematous gastritis is a rare, fulminant manifestation with high mortality. We report a case of a woman in her 80s with multiple comorbidities, including diabetes mellitus and necrotizin...
S. Marsá, Lavender Otom, Priyanka Panwar et al.· ACG Case Reports Journal· 0 citations
Hyperleukocytosis (> 100 × 109/L) is typically associated with hematologic malignancies and is rarely reported in infection. A previously healthy 27‐year‐old man presented with acute gastrointestinal symptoms and was found to have meningococcal bacteremia complicated by thrombocytopenia, coagulopathy, and acute kidney...
C. Gorena, Borna Amir-Kabirian, Ju-Hsien Chao· Case Reports in Infectious D...· 0 citations
Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory response syndrome. Common infectious triggers include Epstein Barr virus, cytomegalovirus, bacteria, and other pathogens. We report a case of HLH caused by human herpesvirus-6 (HHV-6) in a pediatric patient. Based on the HLH-2004 diagnostic criteria, the...
Li-Hong Gao, Yang Wen· Journal of Pediatric Infecti...· 0 citations
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that may mimic severe sepsis, resulting in delayed diagnosis. Bacterial infection-associated HLH is uncommon, particularly with
Klebsiella pneumoniae
. We report a case of a 38-year-old male presenting with community-acquire...
Aparup Dhua, R. S. Ajith, Amit Kumar Manna et al.· MRIMS journal of health scie...· 0 citations
X-linked agammaglobulinemia (XLA) is a rare immunodeficiency caused by a mutation in Bruton's tyrosine kinase, resulting in profoundly low immunoglobulin levels and susceptibility to recurrent infections. We report a 14-year-old patient with XLA who presented with persistent fever, bloody diarrhea, and headache suggest...
G. Sonmez, Cigdem Kaya, Merve Erdem et al.· La Clinica pediatrica· 0 citations
Background and Clinical Significance: Secondary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome that can closely resemble sepsis in adults, potentially delaying recognition and treatment. Because infection may trigger or coexist with HLH, persistent or disproportionate inflamma...
Damián Ochoa Guette, Jennifer Patricia Vargas Gómez, Breallan De Jesús Rómero Pájaro et al.· Reports· 0 citations
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