Topical Delivery of Itraconazole by Clove Oil Based Nanoemulgel for Inhibition of 1ZAP Protein in Candida albicans : Formulation, Optimization, In Silico Study, and Antimicrobial Evaluation

Development and evaluation of clobetasol propionate-loaded nanoliposomal hydrogel integrated with plant-derived microneedle-like microstructures for site-specific psoriasis therapy

Results indicated that the nanoliposomal hydrogel was an effective strategy for the topical delivery of CP, with sustained drug release and enhanced skin deposition via microneedle-like structures for the treatment of psoriasis.

Formulation and evaluation of fluconazole-loaded in situ gel nanoemulsion using polymeric systems for ocular antifungal therapy

Findings suggest that the proposed delivery system represents a promising strategy for improving the ocular bioavailability and therapeutic efficacy of fluconazole in the treatment of fungal eye infections.

Design and Optimization of Hydroxypropyl Beta-Cyclodextrin-Based Miconazole Nitrate Nanosponges Gel for Enhanced Transungual Drug Delivery

Formulation, Optimization, and Characterization, of Allicin-Loaded Β-Cyclodextrin Nanosponges Incorporated into a Topical Gel

Background: Fungal infections remain a significant therapeutic challenge due to recurrence, limited treatment options, and reduced susceptibility to conventional antifungal agents. Allicin, a natural organosulfur compound, possesses promising antifungal activity but requires an appropriate delivery system for effective...

Development and in Vitro Assessment of Cumin Essential Oil Nanoemulsion and Nanoemulgel Formulations for Vaginal Candidiasis

Vaginal candidiasis is a common mucosal infection caused by various Candida species, primarily Candida albicans. Increased drug resistance to current antifungal treatments, high recurrence rates, and local side effects necessitate the development of new and effective carrier systems. This study aimed to optimize nanoem...

FORMULATION AND ANTIMICROBIAL EVALUATION OF A NIOSOMAL GEL INCORPORATING KIGELIA AFRICANA EXTRACT

Topical delivery of herbal antimicrobials is often limited by poor stability and skin penetration of the free extract. This study aimed to develop and evaluate a niosomal gel loaded with the methanolic extract of Kigelia africana for topical antimicrobial application. Niosomes were prepared by the thin-film hydration (...