In this multicenter clinical sample, lithium exposure was consistently associated with lower odds of suicide-related behaviors across multiple analytic approaches and Aggression was independently associated with suicide-related risk and statistically accounted for part of the observed association between lithium exposure and suicide-related outcomes.
Abstract
Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real‐world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized.
Findings reinforce lithium as a first-line treatment for suicide prevention and highlight its comprehensive antisuicidal role-from lower rates of ideation to fewer behaviors-supporting confident, evidence-based clinical use.
Ni Xu, Xiaozhen Lv, Yutong Deng et al.· Journal of Clinical Psychiat...· 0 citations
Overall, these findings suggest that CUD severity is significantly associated with altered outcomes on lifetime suicide attempts and mental health QoL depending on lifetime BD status; however, BD may still play a more prominent role in mental health outcomes, regardless of CUD severity.
Chloe Uelman, M. L. Rogers, Ty S. Schepis· Journal of Psychiatric Resea...· 0 citations
INTRODUCTION
Bipolar Disorders (BD) are severe, recurrent, and well-characterized psychiatric conditions with lithium as the first-line approved treatment for BD. This study aims to evaluate lithium response using the ALDA scale and to identify reliable predictors in a cohort of patients with BD.
METHODS
In this cros...
A. Aguglia, G. Breda, Valentina Aprile et al.· Current Neuropharmacology· 0 citations
Findings highlight an association between depression severity and self-reported stroke history, and both hypertension and diabetes were strong independent predictors of self-reported stroke, while higher income (PIR) was protective.
Himanshu Sharma, K. Reeta· Discover Public Health· 0 citations
Adolescence is a vulnerable period for mental health problems, particularly depression, which has been associated with suicidal behavior. Suicide remains a major public health concern among young people, with 1,350 cases reported in Indonesia in 2023.This analytical observational study used a cross-sectional design imp...
Tadbir Kusuma Putra, I. P. Diatmika, Lale Justin Amelinda Elizar et al.· JURNAL BIOLOGI TROPIS· 0 citations
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