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Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

Sep 2026 · Bipolar Disorders · Vol 28 · 0 citations · 37 references
Medicine

TL;DR

In this multicenter clinical sample, lithium exposure was consistently associated with lower odds of suicide-related behaviors across multiple analytic approaches and Aggression was independently associated with suicide-related risk and statistically accounted for part of the observed association between lithium exposure and suicide-related outcomes.

Abstract

Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real‐world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized.

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