2016· Arteriosclerosis, Thrombosis and Vascular Biology· Vol 36 1, pp. 1· 0 citations· 52 references
Medicine
TL;DR
This proof-of-concept study suggests the potent low-hemorrhage antithrombotic effect of MK by targeting FXIa and unveiling a new therapeutic application of MK.
Cardiovascular diseases remain the leading global cause of morbidity and mortality, and thrombotic events contribute substantially to their clinical burden. Established anticoagulants, including vitamin K antagonists and direct oral anticoagulants, reduce thromboembolic events but remain limited by bleeding risk in sel...
Zhao-Wei Zhu, W. Gong, Xin-Qun Hu et al.· Vessel Plus· 0 citations
A pattern emerges, where FXI/FXIa inhibition offers a favorable safety profile across multiple settings and high-risk subgroups, yet clear efficacy has so far been established only in secondary prevention of noncardioembolic ischemic stroke over existing antiplatelet strategies.
Ermioni Oikonomou, Mark Goldin, A. Spyropoulos· Journal of Clinical Medicine· 0 citations
Only a handful of anticoagulants have reached the clinic to treat and prevent thrombotic episodes in the millions of patients suffering from cardiovascular, cancer, viral (COVID-19) and metabolic diseases. In this work, we report the discovery, chemical synthesis, mechanistic biochemistry, pharmacology, and toxicology...
Chiranjeev Sharma, Rama Gunta, Sridhar R. Iyer et al.· Blood Advances· 0 citations
Anticoagulants are the drugs of choice for the management of various thromboembolic disorders affecting both arteries and veins. This review delineates the pharmacological characteristics of currently available anticoagulants. The potential roles of novel investigational anticoagulants are also briefly discussed. Altho...
Surasak Wichaiyo· Journal of Thrombosis and Ha...· 0 citations
Purpose of review The contact activation pathway, historically considered dispensable for hemostasis, has re-emerged as a critical mediator of thromboinflammation. Plasma prekallikrein, through its activation to kallikrein, links coagulation, inflammation, and vascular biology. This review is timely given increasing in...
Aditya K. Malhotra, Arjun Tomer, Ocean Punsalan et al.· Current opinion in hematolog...· 0 citations
A unified theoretical framework is established, grounded in mechanistic rationale and supported by experimentation, to better define the pharmacodynamics of anticoagulation therapy using thrombin generation as a common language to compare anticoagulant effects across drug classes.
Joseph R. Shaw, Dylan Burger, J. Vassart et al.· Pharmacology and Therapeutic...· 0 citations
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