2015· Arteriosclerosis, Thrombosis and Vascular Biology· Vol 35 1, pp.
1
· 54 citations· 1,463 references
MedicineBiology
TL;DR
The results indicate that cardiopulmonary HIF2 signaling prevents excessive vascular proliferation during chronic hypoxia and define novel protective roles of HIF2 to warrant stable microvasculature and organ function.
OBJECTIVES
Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are rare, severe forms of pulmonary hypertension (PH) characterized by elevated mean pulmonary arterial pressure (mPAP) and ∼20% mortality at 3 years. PAH is defined by progressive obliterative vasculopathy, where...
M. Peracaula, Daniel Aguilar, Á. Vea et al.· Archivos de Bronconeumologia· 0 citations
Cardiac fibrosis, a hallmark of adverse remodeling following myocardial infarction (MI), markedly contributes to progressive heart failure. Severe tissue hypoxia within the ischemic heart activates hypoxia-inducible factor (HIF) signaling, thereby reshaping intercellular communication among non-myocytes. This mini-revi...
Minju Seo, Ye-Ah Kim, Rokhyun Kim et al.· Frontiers in Cell and Develo...· 0 citations
Heart failure is a leading cause of morbidity and mortality worldwide. Emerging evidence points to vascular dysfunction as a major contributor to the development and progression of this grievous syndrome Functional interplay between the myocardium and vasculature involves endothelial cells, vascular smooth muscle cells...
Valeria Garrido-Moreno, A. Ferdous, T. Gillette et al.· Arteriosclerosis, Thrombosis...· 0 citations
Cardiovascular disease (CVD) is a major complication of JAK2V617F-positive myeloproliferative neoplasms (MPNs), yet the mechanisms linking mutant hematopoiesis to CVD remain incompletely understood. We developed three complementary murine models to delineate the role of hematopoietic-endothelial crosstalk in JAK2V617F-...
Hao-Yi Zheng, Hui-Chun Zhan· American Journal of Patholog...· 0 citations
BACKGROUND
Pulmonary arterial hypertension (PAH) is a progressive vascular disorder characterized by pulmonary vascular remodeling and endothelial dysfunction. Although several molecular regulators have been implicated in PAH pathogenesis, the key transcriptional networks governing these processes remain incompletely u...
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary vascular remodeling, leading to hemodynamic impairment and right heart dysfunction, and ultimately right heart failure and death. Despite advances in understanding its pathogenesis, PAH remains associated with poor prognosis and h...
Yan-Qi He, Ying-Ying Zhu, Qing Lv et al.· Frontiers in Immunology· 0 citations
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