reac-Ufm1 inhibits LPS-induced endothelial cell inflammatory responses through the NF-κ B signaling pathway

Dipeptidase-1 Contributes to Sepsis-Associated Endothelial Dysfunction via the EGR1/NF-κB Signaling Axis

It is suggested that DPEP1 may promote NF-κB activation in an EGR1-dependent manner, thereby enhancing inflammatory signaling in endothelial cells in sepsis-associated endothelial cells.

Agonism of GPR84 Attenuates Free Fatty Acid-Induced Endothelial Inflammation and Monocyte Adhesion via Gfi1/NF-κB Pathway.

Farrerol alleviates hepatic ischemia-reperfusion injury by regulating the CD14/MyD88/NF-κB signaling pathway.

Hepatic ischemia-reperfusion injury (HIRI) remains a critical complication in liver surgery with limited pharmacological options, and while Farrerol (FA), a natural dihydroflavone, has shown protective effects in other organ IR models, its role in HIRI has never been explored. In this study, we established a murine mod...

USP40 alleviates atherosclerosis by stabilizing SIRT1 to suppress endothelial apoptosis and NLRP3 inflammasome activation.

Atherosclerosis (AS) is a chronic inflammatory vascular disease driven by endothelial dysfunction, and dysregulated ubiquitination has emerged as an important pathogenic mechanism. Although deubiquitinating enzymes (DUBs) are key regulators of protein homeostasis, the role of USP40 in AS remains unknown. Here, we defin...

L-(+)-Ergothioneine ameliorates preeclampsia-associated vascular endothelial dysfunction by modulating the Nrf2-PPARγ-sFlt-1 axis

L-(+)-ergothioneine improves trophoblast function and indirectly promotes endothelial recovery by modulating the Nrf2-PPARγ-sFlt-1 axis, suggesting a potential therapeutic target for preeclampsia.

FTY720 attenuates LPS-induced acute lung injury through PP2A- tristetraprolin–dependent anti-inflammatory signaling

Acute lung injury (ALI) is characterized excessive inflammatory signaling and uncontrolled cytokine production. Tristetraprolin (TTP) is a key post-transcriptional regulator of inflammatory cytokines that negatively regulates inflammatory pathways. PP2A emerges as an important player to activate TTP. However, wheth...