Aug 2026· ARID International Journal for Science and Technology· 0 citations
TL;DR
A comprehensive machine learning framework to classify ASD severity (mild, moderate, severe) is developed and validates by investigating the differential impact of feature engineering and selection, revealing a critical “evaluation paradox” where radical, unguided feature reduction improved geometric cluster cohesion but degraded clinical accuracy.
Abstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by significant heterogeneity, making the accurate classification of its severity levels crucial for effective intervention. This study develops and validates a comprehensive machine learning framework to classify ASD severity (mild, moderate, severe) by investigating the differential impact of feature engineering and selection. A dataset of 340 individuals was analyzed using a dual-framework approach, integrating supervised classification (SVM, Random Forest, XGBoost) and unsupervised clustering (K-Means, Hierarchical, GMM). The methodology centered on comparing a feature-centric approach, using a hybrid selection strategy on 60 engineered and original features, against a baseline approach using only 33 original features. The feature-centric approach yielded markedly superior results; a Random Forest classifier, trained on a minimal subset of just nine engineered features, achieved a test accuracy of 76.5%, significantly outperforming all other models, including an SVM trained on 22 original features (70.6% accuracy). This highlights that feature quality is more critical than quantity. The unsupervised analysis revealed a critical “evaluation paradox,” where radical, unguided feature reduction improved geometric cluster cohesion but degraded clinical accuracy. Conversely, a guided, domain-informed selection improved both internal and external metrics.
This work aims to inform new ways of modelling ASD using a VAE that will be able to discern between a continuum or a clustered output and that go beyond binary diagnosis, instead reflecting the complex range of trait profiles, with implications for personalised diagnosis and intervention.
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