Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with significant bioaccumulation potential and toxicological concerns. Specifically, perfluorooctane sulfonic acid (PFOS) has been shown to reduce growth, reduce hatching success and decrease hatchling survivability, and arrest develop...
A high-content analysis protocol to assess genotoxicity in human breast epithelial MCF-10A cells by combining micronucleus detection with γH2AX foci quantification demonstrates the potential of high-content, human cell-based approaches for efficient and mechanistically informative genotoxicity assessment.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants widely detected in human biological matrices, including placenta and umbilical cord blood, indicating early-life exposure. Perfluorooctanoic acid (PFOA), one of the most prevalent PFAS, has been associated with endocrine disruption and...
Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic chemicals that are highly persistent in the environment. Several PFAS are detected in blood serum of nearly all people in the United States, and exposure begins in utero. Evidence suggests PFAS may adversely affect child development and immune fu...
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used in industrial and consumer products. Chronic exposure to PFAS has been associated with adverse health outcomes, including kidney cancer, thyroid dysfunction, pregnancy complications, and liver damage. This study investigates the sp...
Per- and polyfluoroalkyl substances (PFASs) commonly occur as complex mixtures, yet the relationships among PFAS structure, cytotoxicity, and DNA strand-break responses remain incompletely resolved. We evaluated 11 PFASs selected to span environmentally prevalent and regulatory-relevant perfluorocarboxylic acids (PFC...
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