ALOX15 orchestrates mitochondrial antiviral immunity and serves as a host target for anti-influenza therapy

Jing-yu Weng Xin-xing Chen Hui-er Ye Ying-Ying Zeng Wan-Li Liang Yin-Ci Zhang Xin-Yu Zong Chang-Yu Yan Yue Ye Yan-Ping Wu Wan-Yang Sun Wen-Jun Duan Lei Liang Yuqi Yan Yun-Feng Cao Yi Dai Hiroshi Kurihara Hao Gao Shu-Hua Ouyang Yi-Fang Li Rong-Rong He

Jul 2026 · Nature Immunology · Vol 27, pp. 1604 - 1618 · 0 citations · 75 references

Medicine

TL;DR

These findings establish ALOX15 as an essential component of mitochondrial antiviral immunity and a promising host-directed target for antiviral therapy, identifying ALOX15 as a host-directed target for anti-influenza therapy.

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