Toward a Vaccine Against Multidrug-Resistant Elizabethkingia anophelis: Comprehensive Immunoinformatics-Based Design of a Multi-Epitope Vaccine and mRNA Construct.
Aug 2026· Probiotics and Antimicrobial Proteins· 0 citations· 153 references
Medicine
TL;DR
This computationally designed hybrid multi-epitope vaccine (MEV) was designed using an extensive immunoinformatics approach targeting four key outer membrane and secretion-associated proteins and offers a promising preventive strategy against E. anophelis infections.
Legionella pneumophila is a Gram-negative opportunistic pathogen responsible for Legionnaires’ disease, a severe form of atypical pneumonia associated with high morbidity and mortality, particularly in immunocompromised individuals. Despite its growing global burden and the persistence of environmental reservoirs, no l...
Lokesh Thangamani, Tong Lian· International Journal of Mol...· 0 citations
The computational analyses support the proposed multi-epitope construct as a potential vaccine candidate against S. haemolyticus and provide a basis for its further experimental evaluation.
Staphylococcus lugdunensis has emerged as an increasingly important opportunistic pathogen associated with invasive infections and rising antimicrobial resistance, creating a need for new preventive approaches. In this study, a reverse-vaccinology strategy integrated with immunoinformatics analyses was applied to genom...
Utilizing in silico, next-generation vaccine design, several vaccine candidates are proposed that warrant further validation through in vitro laboratory testing and in vivo studies to assess their immunological efficacy.
Dania Skhal, Samar Al Nahhas, Osama Skhal et al.· Scientific Reports· 0 citations
An immunoinformatics-guided reverse vaccinology approach to design novel BAFF- and APRIL-adjuvanted multi-epitope vaccine candidates against HMPV identified BAFF- and APRIL-containing multi-epitope constructs with favorable predicted antigenic, physicochemical, structural, and immunological characteristics that warrant...
Reham M. Alahmadi, M. Awadalla, Halah Z. AlRawi et al.· Frontiers in Virology· 0 citations