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A positive feedback loop between YTHDC1 and EP300 drives multiple myeloma tumorigenesis.

Yi-Fan Hou Qi-Qi Shen J. Qu E. Zhang Ru-Yi Xu Hui-Yao Gu Wen Cao Hao-Guang Chen Jin-Na Zhang Shun-Nan Yao Zhen-Feng Dai Hong-Ying Ye Chun-Ting Zhu Yun-Lu Jia Jing-Song He Peng-Xu Qian Zhen Cai
Sep 2026 · Oncogene · 0 citations · 55 references
Medicine

TL;DR

Functional studies reveal that YTHDC1 facilitates MM cell growth and survival in an m6A-dependent manner and highlight the YTHDC1-EP300 axis as a promising target for therapeutic intervention.

DOI PubMed Semantic Scholar
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