Elucidation of HSP90AA1-directed therapeutic mechanisms of Semecarpus anacardium phytocomponents in brain tumors via network pharmacology, target interactome mapping, and molecular simulation analyses

I. U. Haq Abbas Khan S. Saleem Syed Shujait Ali Fahad M. Alshabrmi A. Mohammad Amin F. Majdalawieh A. Agouni Guo-Zhi Yu

Aug 2026 · Network Modeling Analysis in Health Informatics and Bioinformatics · Vol 15 · 0 citations · 75 references

TL;DR

This multi-layered computational investigation suggests that S. anacardium contains phytochemicals with computationally predicted interactions targeting HSP90AA1-associated pathways implicated in brain tumors, and identifies HSP90AA1 as a putative target for future experimental investigation for natural product-guided anti-brain tumor strategies.

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