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Histidine, carnosine, and ergothioneine attenuate pyrazole/LPS-induced hepatotoxicity through modulation of CYP2E1, Nrf2, and NF-κB signaling in mice

İlknur Genç F. H. Karpuzoğlu İlayda Sözmen Serhat Kılınç A. Aydın S. Bağbudar Semen Önder A. Arslan S. Abbasoğlu M. Uysal
Jul 2026 · Molecular Biology Reports · Vol 53 · 0 citations · 76 references
Medicine

TL;DR

Histidine, carnosine, and ergothioneine protected against Pyr + LPS-induced hepatic injury and reduced oxidative stress and were accompanied by alterations in CYP2E1 protein levels and NF-κB/Nrf2/HO-1-related gene expression; however, further studies are needed to clarify the underlying mechanisms.

DOI PubMed Semantic Scholar
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