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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

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Open access Sep 2026

Integrated map of somatic mosaicism across human tissues in 25 individuals

The first integrated analysis of the Somatic Mosaicism across Human Tissues (SMaHT) Network’s production resource is presented, profiling up to 20 tissues from 25 donors using short- and long-read, duplex, single-cell, transcriptomic, and epigenomic sequencing, alongside donor-specific near-telomere-to-telomere assembl...

F. Sedlazeck, Tim H. H. Coorens, Peter J. Park et al. · 2 citations
Review Sep 2026

Single-cell and spatial transcriptomic technologies for lung cancer tumor microenvironment analysis.

How spatially structured cellular ecosystems, rather than individual cell types, determine therapeutic response and resistance in lung cancer is organized around a single question - and observations that are reproducible across independent cohorts and platforms are explicitly separate from those that remain confined to...

C. Braicu, R. Pîrlog, A. Nutu et al. · 0 citations
Open access Aug 2026

Closing the fusion-detection gap in single-cell RNA-seq with a scalable, probe-based workflow

Single-cell RNA-sequencing resolves cellular states in exquisite detail. Yet oncogenic gene fusions, key drivers in 16.5% of malignancies and ∼50-70% of acute lymphoblastic leukaemia (ALL) cases, remain largely invisible at this resolution. This leaves a fundamental gap in understanding cancer biology. We close it with...

Jovana Maksimovic, Victoria Streeton-Cook, Calandra V. Grima et al. · 0 citations
Open access Sep 2026

The lifelong transcriptomic landscape of human blood cells.

A panoramic landscape of the human hematopoietic system is established and its lifelong behaviors are elaborated, in which a steady-state reference enabled the delineation of pathological hallmarks across hematological malignancies.

Xiao-Wei Xie, Lian-Shuo Li, Fang Hong et al. · 0 citations
Open access Sep 2026

Single-Cell Indel Detection Enhances Genetic Ancestry and Cellular Lineage Analysis

Small insertions and deletions (Indels) provide critical information for cancer genomics and clonal evolution, yet their detection from single-cell sequencing (SCS) such as scRNA-seq and scATAC-seq remains challenging due to sparse coverage, alignment artifacts, and RNA editing. Here, we present Monopogen-Indel, a bioi...

Zi-Yi Wang, Ken Chen, J. Dou · 0 citations
Open access Oct 2026

Reduced Gene Module for Spatial Transcriptomics Recapitulates Single-Cell Molecular Classifications of Glioblastoma.

Glioblastoma, IDH-wildtype, is the most common and malignant adult-type diffuse glioma. It is characterized by extensive heterogeneity and poor prognosis. Recent single-cell RNA-sequencing studies have revealed distinct transcriptional programs that define cellular states such as astrocyte-like, mesenchymal-like, neura...

Koki Ise, Zen-ichi Tanei, Takeru Kuwabara et al. · 0 citations

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