Single-nucleus RNA sequencing reveals excitatory and inhibitory neuronal subtype imbalance and its potential regulatory mechanisms in GM1 gangliosidosis.
A comprehensive analysis of single-nucleus sequencing data of GM1 gangliosidosis has revealed the key cell subpopulations and their related functions in these diseases, providing a theoretical basis for the mechanism of disease occurrence and possible treatment strategies.
This dataset defines transcriptomic programs underlying key cellular alterations in TLE, enabling mechanistic dissection of epileptogenesis, and term this microglia population epilepsy-associated microglia (EAM).
Victoria Ho, Ruth Tjondropurnomo, Jennifer Nguyen et al.· iScience· 0 citations
The mechanisms underlying type 2 diabetes-associated cognitive dysfunction (DACD) remain poorly understood, hindering therapeutic progress. Here, we integrated spatial transcriptomics and single-nucleus RNA sequencing to delineate the spatiotemporal molecular and cellular landscape of DACD in brain tissues from 3- and...
Wei Wu, Yu-Meng Yang, Xi-Xi Zhang et al.· Proceedings of the National...· 0 citations
Cell-type specific vulnerabilities to STXBP1 haploinsufficiency are identified which may explain hyperexcitability, network dysfunction and cognition deficits in STXBP1-RD, providing potential new therapeutic targets.
A. R. Adam, A. V. van Berkel, M. Vanheusden et al.· Molecular Psychiatry· 0 citations
Microglia-regulated neuroinflammation is associated with major depressive disorder (MDD), yet the molecular drivers of pathological microglia-neuron interactions remain poorly defined. Here, we conducted single-nucleus RNA sequencing (snRNA-seq) of the prefrontal cortex (PFC) in mice susceptible to chronic social def...
Rui-Min Tian, Hong-Zhou Zuo, Chen-Chen Tang et al.· Journal of Neuroinflammation· 0 citations
AIMS
This study aims to systematically identify the cellular drivers of brain microenvironmental imbalance during Alzheimer's disease (AD) progression by integrating high-resolution single-nucleus RNA sequencing (snRNA-seq) with intercellular communication analyses. In the work, the functional transitions and metabolic...
Xue-Man Xie, Wen-Jing Liu, Long-Chao Chen et al.· Life Science· 0 citations
Neuroligins are synaptic adhesion molecules important for neurodevelopment, and rare, highly penetrant variants underlie neurodevelopmental disorders (NDDs). Here, we characterize a rare missense variant NLGN4X G243R identified in a pedigree with NDDs and associated with severe protein trafficking deficits. NLGN4X G2...
E. Hong, Miriam Reyes Mendez, C. Guissart et al.· Translational Psychiatry· 0 citations
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