Aug 2026· The Journal of pharmacy and pharmacology· Vol 78 8· 0 citations
Medicine
TL;DR
This review consolidates current knowledge on MEG3, detailing its genetics, expression regulation, and core mechanisms-primarily its role as a competing endogenous RNA (posttranscriptional regulation) and as a scaffold for chromatin modifiers to modulate inflammatory pathways.
This work provides a comprehensive framework that clarifies recent controversies—such as whether H4K16ac primarily governs transcription or replication timing, and which KAT8-containing complex catalyzes, which acetylation mark—and establishes a rationale for future precision-targeting strategies and biomarker developm...
This review systematically summarizes recent advances in the molecular mechanisms and physiological functions of TET2, and highlights its disease-specific roles and promising therapeutic strategies.
Jingyi Tang, Ruoxian Wang, Li Long et al.· Frontiers in Immunology· 0 citations
This review systematically consolidates recent advances in understanding how lncRNAs precisely modulate Notch pathway activity through diverse mechanisms, including acting as competing endogenous RNAs, direct protein binding, epigenetic regulation, and exosome-mediated intercellular communication.
Qing-Miao Shi, Na Lou, Huiwu Xing et al.· Frontiers in Cell and Develo...· 0 citations
This narrative review examines the mechanistic roles of major asthma-associated miRNAs, evaluates circulating and extracellular-vesicle miRNAs as clinical biomarkers, and appraises preclinical therapeutic modulation strategies.
Siddarth Raajasekar· Genetics and Molecular Resea...· 0 citations
This review examines NLRP3 biology across three interconnected dimensions: cellular context, including immune and non-immune compartments; microenvironmental context, including infectious versus sterile inflammation and tissue repair versus tissue damage; and disease context, including stage- and time-dependent functio...
Shuo Liu, Xun Liu, Jing Hu et al.· Journal of Translational Med...· 0 citations
This review systematically elucidate how hyperglycemia, oxidative stress, and inflammation disrupt sodium, calcium, potassium, and chloride channel networks through interconnected pathways such as AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR), NLR family pyrin domain containing 3 (NLRP3), and...
Xi Xiong, Bao Yan, Bin Ke et al.· American journal of translat...· 0 citations
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