Sep 2026· Diabetes, obesity and metabolism· Vol 28, pp. 11775 - 11784· 0 citations· 31 references
Medicine
TL;DR
Marked BW change was associated with subsequent dementia risk in young and middle-aged adults with T2DM and depression, and BW trajectories may serve as clinically observable risk markers, although associations involving extreme BW change should be interpreted cautiously.
Abstract
Type 2 diabetes mellitus (T2DM) and depression are established risk factors for dementia, yet clinically observable markers of neurocognitive vulnerability in younger adults with these comorbidities remain poorly characterized. We examined whether longitudinal body weight (BW) change is associated with incident dementia in young and middle‐aged adults with T2DM and depression.
Adverse SDOH was associated with higher dementia risk, with stronger T2D-related risk among medium/unfavorable SDOH groups, especially in women with T2D.
Background: Although the frailty index (FI) has been reported to associate with stroke risk in older adults, its relationship in those with gastrointestinal (GI) or liver diseases remains unclear. We examined this association in a Chinese cohort with these comorbidities. Methods: Using baseline data from the China Heal...
Xiao She, Hai-Yan Yang, Xiao Zhao et al.· Journal of Clinical Medicine· 0 citations
Depression is associated with greater risks for incident cardiovascular disease and all-cause death in people with type 2 diabetes and minor contributions from metabolic risk factors on these associations, highlighting the need for enhanced screening for depression and integrated care.
E. W. Chow, E. Lau, Hong-Jiang Wu et al.· Journal of Affective Disorde...· 0 citations
The associations between modifiable risk factors and incident Alzheimer's disease dementia exhibited distinct sex- and age-specific patterns, highlighting the importance of tailored dementia prevention strategies that account for differences in demographic characteristics and risk factor profiles.
H. J. Kim, M. Oh· Journal of Evidence-Based Pr...· 0 citations
Integrating metabolic and mental health screening and interventions may optimize cognitive outcomes in high-risk older adult populations, with a significant additive interaction between diabetes and depressive symptoms found only in the CHARLS cohort.
Background Type 2 diabetes mellitus (T2DM) is a well-established risk factor for dementia, and COVID-19 has been associated with persistent neurological and cognitive sequelae. However, whether this association extends beyond the early post-infection period among older adults with T2DM—a population with compounded vasc...
I.-W. Chen, Li-Chen Chang, C. Ho et al.· Frontiers in Aging Neuroscie...· 0 citations
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