The modulatory role of Sirtuins in FOXP3 expression and Treg differentiation is reviewed, providing insight into their contribution to tumor immunosuppression and integrating network-based analysis identified miR-34a as a central regulator and validated the miRNA-Transcription Factor-Sirtuin axis as a viable framework for cancer therapeutic targeting.
A SIRT context code is defined in which NAD+ availability and compartmentalization, subcellular localization, PTM state, chromatin occupancy, oncogenic genotype, cell lineage, and tumor microenvironment jointly determine sirtuin output, arguing that successful sirtuin pharmacology will require context matching rather t...
Abdelwahab Aly, Zhi-Qing Tan, S. Sasidharan et al.· Critical reviews in oncology...· 0 citations
Which aspects of SIRT modulation are most promising and under what isoform, tissue, and disease contexts they should be pursued for the development of SIRT‑targeted therapies in human disease are clarified.
This review synthesizes the emerging roles of SIRT5/7-mediated desuccinylation in cancer metabolism, immunity, and drug resistance, highlighting their potential as targets for synergistic metabolic-immunotherapy interventions.
P. Luo, Xing-Hua Long· Biochemical Pharmacology· 0 citations
The molecular characteristics and regulatory properties of DHX9 are summarized, its roles in genome stability, transcriptional and post-transcriptional control, circular RNA biogenesis, and tumor-immune crosstalk are discussed, and its emerging value as a potential biomarker and therapeutic target is evaluated.
Yejin Cai, Ziyuan Chen, Jia-Ying Xiong et al.· Biochimica et biophysica act...· 0 citations
This review explores the mechanistic involvement of UBE2C in diverse cancers, with a particular focus on its involvement in DNA damage repair mediated by the anaphase-promoting complex (APC/C).
The data demonstrate that SIRT3 does not play a major role in cancer cell death induced by the conventional chemotherapeutic drug cisplatin but exerts a protective role in the case of the mitochondria-targeting agent α-TOS.
M. A. Yapryntseva, М. А. Виноградов, P. I. Volik et al.· Cell Communication and Signa...· 0 citations
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