TL;DR
Higher circ_0027446 expression was associated with larger tumor size, lymph node metastasis, advanced TNM stage, and shorter overall survival, and may contribute to tumor progression and immune escape-related changes, at least partly through the miR-6882-3p/HOXB9 axis.
In vivo, circPVT1 promoted tumor growth and lung metastasis, which were attenuated by co-expression of miR-195-5p, and molecular analysis of lung metastases confirmed the dysregulation of the circPVT1/miR-195-5p/PDK4 axis within metastatic lesions.
As an oncogenic circRNA, hsa_circ_0001839 is critically implicated in gastric cancer progression and unfavorable patient outcomes, underscoring its dual application as a promising prognostic biomarker and a potential therapeutic intervention target.
circ_0075961 is associated with malignant phenotypes in LSCC, including tumor cell proliferation, migration, invasion, and EMT, with these effects potentially linked to ZEB1 regulation.
It is demonstrated that circGABRB2_006 drives malignant progression of PTC through the miR-296-5p/FGFR1 signaling axis, highlighting its potential as a biomarker and therapeutic target in PTC.
A previously unrecognized NCOA5–ZCCHC3/FGF22 axis that drives LUAD progression is identified and new mechanistic insight is provided into the role of NCOA5 in LUAD biology.
Cervical cancer is a leading cause of female malignancy worldwide. While microRNA-4327 (miR-4327) has been implicated as a potential oncogene, its functional role and molecular mechanisms in cervical cancer pathogenesis remain unclear. This study aimed to determine the oncogenic function of miR-4327 and elucidate its d...
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