The study demonstrates that TFEB regulates the expression of the multidrug efflux transporter ATP-binding cassette subfamily G member 2 (ABCG2), a crucial factor in drug resistance mechanisms, and targets TNKS represents a potentially effective therapeutic approach to address cisplatin resistance and improve treatment outcomes in TNBC.
It is demonstrated that reversing epigenetic changes in TNBC-derived cell lines significantly alters HOX expression and generally reduces sensitivity to HTL-001, and HTL-001 shows synergistic interactions with several established chemotherapeutic agents in vitro.
Richard Morgan, Guy Simpson, E. Arunachalam et al.· Current Issues in Molecular...· 0 citations
A novel EFO2/USF1/SLC2A1 signaling axis that modulates glycolytic metabolism and CD8⁺T cell cytotoxicity is identified, positioning EFO2 as a promising therapeutic target for TNBC treatment.
Lin Jia, Liru Li, Junning Peng et al.· Biochemical Pharmacology· 0 citations
In MCF-7 and MDA-MB-231 cells, TBX20 overexpression significantly enhanced cell proliferation, migration, invasion, and resistance to doxorubicin, while suppressing the expression of mitophagy-related proteins LC3-II/LC3-I, PINK1, and BNIP3.
Shuai Nie, Dejian Liu, Jun Hu et al.· PLoS ONE· 0 citations
Objectives: As an aggressive subtype of breast cancer, triple-negative breast cancer (TNBC) is constrained by the limited availability of effective treatments and the absence of well-validated therapeutic targets. This study aimed to explore whether honokiol, a potent YAP/TAZ inhibitor, suppresses stem cell–like proper...
This is the first study to demonstrate that Cal exerts anti-TNBC activity through a novel OTUD6B/GPX4-dependent ferroptosis regulatory axis and highlights that Cal warrants further investigation as a potential candidate, and the OTUD6B/GPX4 signaling pathway may represent a significant target for TNBC treatment.
Xue Mao, Yin Lin, Zhifeng Gu et al.· Biochemical and Biophysical...· 0 citations
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