Upregulation of paraoxonase-2 enzyme in human osteosarcoma and its involvement in mechanisms promoting the aggressive behavior of tumor cells

Eleonora Gerini Veronica Pompei M. Cecati R. Campagna V. Pozzi Alessandra Filosa Gaia Goteri E. Salvolini M. Emanuelli D. Sartini

Aug 2026 · Molecular Biology Reports · Vol 53 · 0 citations · 46 references

Medicine

TL;DR

PON2 appears to sustain chemoresistance by affecting important mechanisms related to ROS detoxification, glucose metabolism, and anti-apoptotic signaling by affecting important mechanisms related to ROS detoxification, glucose metabolism, and anti-apoptotic signaling.

DOI PubMed Semantic Scholar

View source

Similar papers

drug resistance via HOXA9 in colorectal carcinoma cells

It is demonstrated that NAC1 may be a critical factor in the development of chemoresistance, offering a potential novel target for the treatment of CRC.

Tong-Fa Ju, Huicheng Jin, Rongchao Ying et al. · 0 citations

Open access 2026

Low Expression of ARHGAP40 in Colorectal Cancer Facilitates Tumor Progression by Activating the RhoA Pathway

ARHGAP40 is downregulated in CRC, and its loss may contribute to tumor progression, possibly through dysregulation of RhoA activity.

Bin Lian, Na You, Jing-Yu Wang et al. · Biocell (Mendoza) · 0 citations

Open access Aug 2026

KIAA1429 knockdown alleviates osteosarcoma progression by destabilizing SLC7A11 mRNA via m6A methylation to promote ferroptosis

KIAA1429 knockdown may suppress OS progression by inhibiting m6A-dependent SLC7A11 expression, thereby promoting ferroptosis and targeting the KIAA1429/SLC7A11 axis may represent a promising therapeutic strategy for OS.

Hui Zeng, Yun-Yan Zhong, Ding-Biao Zeng et al. · International Journal of Onc... · 0 citations

Open access Jul 2026

IGF2BP1 promotes gastric cancer progression by stabilizing HS6ST2 mRNA in an N6-methyladenosine-dependent manner

It is demonstrated that IGF2BP1 drives GC progression by stabilizing HS6ST2 mRNA via m6A modification and the IGF2BP1/HS6ST2 axis may serve as a potential prognostic biomarker and therapeutic intervention for GC.

Lu Liu, Yi-jing Zhou, Yue Xu et al. · World Journal of Gastrointes... · 0 citations

Jul 2026

Abstract A007: Hsp27 Mediates Sensitivity to Gemcitabine through Mitophagy Regulation in Osteosarcoma

Hsp27 expression modulates both basal and GCB-induced mitophagy in osteosarcoma, suggesting that targeting Hsp27-regulated mitophagy may enhance therapeutic response to gemcitabine.

Yan Zheng, Nancy Gordon, Ariana Anjer et al. · Cancer Research · 0 citations

Open access Aug 2026

DSCAM‐AS1 Facilitates Osteosarcoma Progression via Regulating miR‐211‐5p/PDCD6 Axis

Functional loss‐of‐function experiments demonstrated that silencing (knockdown) of DSCAM‐AS1 expression substantially diminished OS cell proliferation, migration, and invasion, while simultaneously promoting cellular apoptosis in vitro.

Qi Wang, Yun-Zheng Zhao, Long-Bao Shi et al. · Drug development research (P... · 0 citations