THE IMPACT OF LIFESTYLE: THE EFFECTS OF DIET, EXERCISE AND INOSITOL SUPPLEMENTATION ON THE COURSE OF POLYENDOCRINE METABOLIC OVARIAN SYNDROME (PMOS): NARRATIVE REVIEW
Abstract
Background Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome (PCOS), is a complex endocrine and metabolic disorder associated with insulin resistance, hyperandrogenism, ovulatory dysfunction, and metabolic complications. Lifestyle modification is considered an important component of PMOS management. Aims To summarize current evidence regarding the effects of dietary interventions, physical activity, sleep quality, and inositol supplementation in women with PMOS. Materials and methods A narrative review of the literature was conducted using the PubMed and Google Scholar databases. The final literature search was performed on July 8, 2026. English-language peer-reviewed publications published between 2009 and 2026, including systematic reviews, meta-analyses, randomized controlled trials, cohort and observational studies, narrative reviews, and case series, were analyzed. Earlier landmark studies and international clinical guidelines were included when relevant. Following literature screening and eligibility assessment, 49 publications were included. Results Current evidence suggests that dietary modification, regular physical activity, and inositol supplementation may improve insulin resistance, menstrual regularity, ovulatory function, hyperandrogenism, and selected metabolic parameters. Sleep disturbances are common in women with PMOS and appear to be associated with adverse metabolic and psychological outcomes; however, evidence regarding sleep interventions remains limited. Conclusions Lifestyle modification may support the comprehensive management of PMOS. The strongest evidence supports dietary interventions, physical activity, and inositol supplementation, whereas further high-quality studies are needed to clarify the role of sleep optimization and determine the long-term effectiveness of individual lifestyle interventions.