Aug 2026· Oncogene· Vol 45, pp. 4065 - 4076· 0 citations· 40 references
Medicine
TL;DR
Collectively, MS-PDOs serve as a robust platform for modeling the tumor microenvironment and predicting therapeutic responses, supporting precision medicine-guided clinical decision-making and offering personalized treatment strategies for HNSCC patients.
Patient-derived tumor organoids (PDOs) closely preserve the cellular heterogeneity, histopathology, and molecular features of the original tumors, making them powerful preclinical models. Antisense oligonucleotides (ASOs) are an emerging class of precision medicines that modulate gene expression at the RNA level with h...
Thi Thom Tran, Thi Thuc Uyen Phan, M. Baboudjian et al.· Advanced Healthcare Material...· 0 citations
The tumor microenvironment (TME) is a dynamic and immunosuppressive niche that critically governs cancer progression, immune evasion, and therapeutic resistance. Accurately modeling tumor–immune interactions in vitro is therefore essential for advancing our understanding of cancer biology and accelerating the developme...
Mohamed Gadelkarim, Ahmed Elsayed, Tasneem Abaza et al.· Clinical Cancer Bulletin· 0 citations
Background/Aim: The present study aimed to establish patient-derived organoid (PDO) and patient-derived xenograft (PDX) models from clinical gastric cancer (GC) tissue samples and analyze their drug sensitivity data to evaluate their translational value in GC research. The present study investigated the integrated cons...
Prostate cancer ranks among the most prevalent male malignancies worldwide, with castration-resistant prostate cancer (CRPC) and drug resistance representing major clinical challenges. Conventional preclinical models fail to faithfully recapitulate tumor heterogeneity and the tumor microenvironment (TME). Patient-deriv...
Jing-Zhen Zhu, Sheng Wang, Fu-Rong Du et al.· Frontiers in Oncology· 0 citations
Patient-derived organoids (PDOs) represent a promising precision medicine approach for replicating primary tumor characteristics and facilitating drug testing across various cancers, although clinical evidence in bladder cancer remains limited. This study evaluates the impact of incorporating PDOs into clinical pract...
Chemotherapy is a standard treatment for lung adenocarcinoma (LUAD), yet the efficacy is often limited, highlighting the need to elucidate and the underlying mechanisms of chemoresistance. Given the important role of the tumor microenvironment in LUAD progression, we established a biobank of patient-derived LUAD organo...
Si-Qi Li, Ze Zhang, Quan-Kun Lv et al.· Cancer Research· 0 citations
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