2026· Methods in molecular biology· Vol 3054, pp.
15-27
· 0 citations
Medicine
TL;DR
A bioinformatics approach combining plantiSMASH and MCScan for the identification, annotation, and comparative analysis of BGCs in plant genomes, which can significantly enhance research in plant genomics and metabolic engineering by offering new insights into the organization and function of BGCs.
Understanding of the metabolic capabilities and genomic landscape of the P. fluorescens species is enhanced, providing a foundation for natural product discovery using bioinformatic approaches.
Sajid Iqbal, Farida Begum· Discover Genetics and Evolut...· 0 citations
Genome-wide identification of plant gene families is essential for functional and evolutionary studies but often requires the use of multiple independent tools for homolog detection, domain validation, orthology assignment, and phylogenetic analysis. This fragmented approach involves extensive manual scripting, complic...
Sanam Parajuli, Bibek Adhikari, Anne Y. Fennell et al.· bioRxiv· 0 citations
A comparative genomic analysis of BGCs across the allotetraploid Coffea arabica and its diploid progenitors advances understanding of specialized metabolism in Coffea and identifies targets for coffee improvement and climate resilience.
D. Chacon, Laura González García, Vitor Trinca et al.· Genome· 0 citations
The modular and reproducible architecture of the BGX pipeline provides an effective framework for large-scale genome mining, genomic surveillance, and accelerates the discovery and prioritisation of novel secondary metabolites.
The effectiveness of integrated genome-mining strategies for prioritizing cryptic biosynthetic gene clusters is demonstrated and the remarkable biosynthetic potential of newly identified Streptomyces isolates as a source of novel natural products is highlighted.
Nada S. Al-Theyab, Haila M. Alnassar, Mohanad A. Ibrahim et al.· Frontiers in Microbiology· 0 citations
This work identifies the putative myriocin biosynthesis gene cluster (BGC) through de novo sequencing of two producing fungi, Isaria sinclairii and Mycelia sterilia, yielding genomes of 27 and 20 secondary metabolite BGCs, respectively.
B. Rutter, Michael A. Herrera, Gustavo Perez Ortiz et al.· Communications Biology· 0 citations
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