Findings reveal tissue-specific metabolite accumulation and key genes involved in MIA biosynthesis in N. cadamba that provide valuable insights into specialized metabolism and establish a foundation for future metabolic engineering and functional genomics studies.
This work provides a foundational resource for C. diurnum for future pharmaceutical and biotechnological applications, enables the discovery and functional characterization of candidate genes, supports metabolic engineering strategies to enhance valuable terpenoids, and offers avenues to mitigate toxic alkaloid accumul...
Vandana Mathur, Ramawatar Nagar, Maniraj Rathinam et al.· Physiology and Molecular Bio...· 0 citations
This review compares the historical and methodological trajectories that have shaped IA and AA pathway elucidation, from compound isolation, radiotracer experiments, and biochemical inference to transcriptomics, metabolomics, functional enzymology, isotope-guided active-tissue identification, regulatory studies, and he...
Mateo Peña-Morales, J. D. Vega-Páez, Natalie Cortes et al.· Plants· 0 citations
Key genes in the mevalonate (MVA) pathway were upregulated in roots, facilitating metabolic crosstalk with the methylerythritol-phosphate pathway and enhancing terpenoid skeleton synthesis.
The observed patterns are consistent with coordinated changes in hormone-related metabolites, secondary metabolism, and gene expression during root enlargement, and for guiding future functional and targeted validation studies in this endangered medicinal species.
72 candidate genes from seven enzyme families potentially involved in the synthesis of the HupA backbone are identified, including lysine/ornithine decarboxylases, copper amine oxidases, chalcone synthases, and cytochrome P450 monooxygenases.
Ming Lei, Jing Wang, Cui Li et al.· Horticulturae· 0 citations
This study clarifies the molecular basis and transcriptional regulation of phenolic acid glycosylation in P. chienii, providing a framework for exploiting its medicinal resources and guiding conservation-oriented breeding.
Xiaori Zhan, Zijing Zhou, Yuting Peng et al.· Plant and Cell Physiology· 1 citation
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