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Increased expression of developmental Nav1.3 promotes hippocampal CA3 hyperexcitability in early-stage 5xFAD mice

Jiabin Tang Cameron Swope Kishan Patel Azliana Jusnida Ahmad Jafri Jiaxin Xiang Teresa A. Milner Hugh C. Hemmings J. Platholi

Jul 2026 · bioRxiv · 0 citations

Biology Medicine

TL;DR

It is shown that Nav1.3, a subtype normally confined to early development, shows aberrantly increased expression in the dentate gyrus (DG)-CA3 circuit in early-stage 5xFAD mice, which is identified as a driver of early hippocampal network dysfunction in AD.

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