Generation of the induced pluripotent stem cell line SHUTCMi001-A from a patient with double primary lung and colon cancers.

Abstract

Patients with synchronous multiple primary malignancies often exhibit unique genetic susceptibility. Here, we generated the induced pluripotent stem cell (iPSC) line, SHUTCMi001-A, from a 70-year-old patient with double primary lung squamous cell carcinoma and sigmoid colon adenocarcinoma with wild-type driver genes. The iPSC line maintained a normal karyotype, expressed markers of the undifferentiated hPSC state, and demonstrated three-germ-layer differentiation capacity, providing a valuable resource for studying the biological features of synchronous multiple primary malignancies.