Jul 2026· Current Drug Discovery Technologies· 0 citations
Medicine
TL;DR
How pharmacogenetics and pharmacogenomics function as enabling technologies across the pharmaceutical and clinical domains is synthesized, with emphasis on biomarker-guided drug development, patient stratification, safety optimization, regulatory translation, precision oncology, sex-related variability, population diversity, artificial intelligence, and multi-omics integration.
The integration of pharmacogenomics into routine healthcare has the potential to optimize individualized drug therapy, minimize preventable ADRs, and accelerate the transition toward precision medicine, ultimately improving clinical outcomes and healthcare quality.
Rayapudi Vasavi Sai Saraswati, U. Vattikuti, Arthika Chauhan Laudia et al.· International Journal of Cur...· 0 citations
The integration of artificial intelligence and machine learning approaches for pharmacogenomic prediction, the emergence of polygenic risk scores, and the role of multi-omics integration in refining therapeutic decision-making are examined.
Hao Sun, Zijun Qiao, Jinze Yu et al.· Brazilian Journal of Science· 0 citations
A critical evaluation of clinically validated PGx biomarkers for chemotherapeutics and targeted therapy with a focus on translational relevance and strength of evidence shows high-impact germline markers such as DPYD, TPMT, NUDT15 and UGT1A1 are highlighted as key determinants of genotype-guided dosing for improving sa...
Satyam Kumar Vishwash, Ram Babu Soni, Sourabh Kosey et al.· Journal of chemotherapy· 0 citations
The convergence of medicinal chemistry and pharmacogenomics may offer a promising framework to enhance safety and precision in off-label prescribing in populations insufficiently represented in clinical trials.
Mariana Meira Scudeler, Isadora Renck Scherer, Gabriel Vaisam Castro et al.· Mini-Reviews in Medical Chem...· 0 citations
Developments support a transition from concentration-guided dosing toward mechanism-informed precision pharmacotherapy that integrates drug exposure with biological response and clinical outcomes while maintaining rigorous standards for validation and regulatory acceptance.
Ian Jenkins, Krista Casazza, Waldemar Lernhardt et al.· Pharmaceutics· 1 citation
Overall, pharmacogenomic-guided dose adjustment is a promising strategy to support safer and more precise pharmacotherapy, although broader implementation requires standardized guidelines, prospective validation, population-specific evidence, and integration into routine healthcare systems.
Zakiah Thahir, Rahmah Mustarin, Rahmadani Rahmadani et al.· Indonesian Journal of Pharma...· 0 citations
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