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Oligodendroglial deletion of the microcephaly gene Cit-k disrupts cortical connectivity and cognitive function

Martino Bonato F. Marchiotto Maryam Khastkhodaei Ardakani Federico G. P. Ferrari Niccolò Di Cintio Annamaria Renna O. M. Roggero F. Montarolo V. Cerrato A. Frasca B. Sacchetti A. Buffo M. Cambiaghi Enrica Boda
Aug 2026 · bioRxiv · 0 citations · 16 references
Biology

TL;DR

It is shown that oligodendroglial Cit-k loss and the resulting hypomyelination are sufficient to produce long-lasting neurological and behavioral impairments independently of primary neuronal defects.

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