Aug 2026· Analytical Methods· 0 citations· 37 references
Medicine
TL;DR
A label-free, rapid, and cost-effective platform offering a highly promising tool for point-of-care carcinoid screening and neuroendocrine biomarker monitoring, functionalized with in situ grown gold nanoflowers (AuNFs).
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) is a critical biomarker for carcinoid tumor diagnosis, yet its precise quantification in clinical settings remains challenging. Herein, we develop a high-performance optical fiber localized surface plasmon resonance (LSPR) biosensor functionalized with in situ grown gold nanoflowers (AuNFs). The hierarchical branched architecture of AuNFs concentrates electromagnetic fields into dense nanoscale "hotspots", delivering a ∼2.2-fold signal amplification compared to spherical AuNPs. Integrated with a specific 5-HT aptamer, the sensor achieves a wide linear range (10-1000 ng mL-1) and a low limit of detection (7.06 ng mL-1), seamlessly covering physiological to pathological concentrations. Validation in human serum confirms excellent accuracy with recoveries of 99.9-102.9%. This label-free, rapid, and cost-effective platform offers a highly promising tool for point-of-care carcinoid screening and neuroendocrine biomarker monitoring.
The results establish the MOF-SERS-integrated fiber probe as a potential powerful platform for remote and flexible neurochemical sensing in complex biological matrices, with strong promising for clinically relevant bioanalysis.
This work introduces a dual-modality analytical platform based on laser-induced graphene (LIG) for the label-free, noninvasive detection of the prostate cancer biomarker sarcosine in human urine. The tunable porosity and high conductivity of LIG enable its bifunctional application as both a sensitive electrochemical el...
Fiber-optic biosensors based on interferometric structures have attracted considerable attention for rapid and label-free biomarker detection; however, achieving high sensitivity while maintaining practical applicability in complex biological matrices remains challenging. Here, we develop a tapered seven-core fiber (TS...
Tong-Yuan Kang, Li-Juan Yuan, Ruiduo Wang et al.· Talanta: The International J...· 0 citations
A dual-mode colorimetric–photothermal LFIA platform was successfully constructed for the detection of thrombosis-related biomarkers, including thrombomodulin and α2-plasmin inhibitor–plasmin complex, in clinical serum samples, enhancing analytical sensitivity and reliability.
Jun Yin, Yu Qiu, Yao Nie et al.· RSC Advances· 0 citations
The first optoelectronic biosensor that employs plasmonic hot carriers for signal transduction is reported, establishing plasmonic hot carriers as a promising transduction mechanism for scalable and multiplexed bio‐ and chemical sensing platforms.
T. Nguyen, Heongkyu Ju, Seon Seok Joo et al.· Advanced Functional Material...· 0 citations
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