Meta-analysis of insights into HHEX (rs1111875) and SLC30A8 (rs13266634) gene variants and type 2 diabetes mellitus

Abstract

Type 2 diabetes mellitus (T2DM) is aggravated by inherited factors, peripheral insulin resistance and environmental factors. Genome wide association studies (GWAS) revealed more than 400 genetic loci to be associated with T2DM. The function of HHEX gene rs1111875 variant and the insulin secretion response after a glucose load might impact the risk of T2DM mainly via altering pancreatic β-cell activity. The solute carrier family 30, member 8 (SLC30A8) is primarily expressed in pancreatic β-cells and may play a key role in insulin secretory pathway. This current study revealed a significant association between HHEX A>G variant and T2DM in allele (A versus G: p=0.004), Codominant (AA versus GG: p=0.001), Dominant (AA versus AG + GG: p=0.02) and recessive (AA+AG versus GG: p=0.002) inheritance models and for HHEX C>T variant under recessive inheritance model (CC+CT versus TT: p=0.035). In addition, for SLC30A8 C>T variant also associated with T2DM under allele (C versus T: p=0.001), dominant (CC versus CT+TT: p=0.001), recessive (CC+CT versus TT: p=0.001), codominant [(CC versus CT: p=0.007) and (CC versus TT: p≤0.001)] inheritance models. HHEX (rs1111875) and SLC30A8 (rs13266634) gene variants revealed that these gene variants can be a potential factor for etiopathogenesis of T2DM.