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Distinct Motor Cortex Somatotopy in Experimental Alzheimer’s Disease

SE Moss Cassandra C. Wolsh Rmii Brown AR Brown S. Manchikalapudi D. Beversdorf L. Ma Jeffery A. Boychuk
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

Progressive, age-dependent remodeling of motor cortex somatotopic remodeling is demonstrated in 5XFAD mice, characterized by early expansion of specific simple movement cortical sites followed by deterioration of both complex and simple motor cortical maps as disease advances.

DOI Semantic Scholar
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