Skip to content
Log in
Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Neuromodulatory roles of the sigma-1 receptor in behavior and drug sensitization during development.

Qian Yang Jia-Hui Xiao Jia-Yuan Li Zhe-xiang Yu Pingping Qin Yi Zhu Na Ye Xin-Hao Li Shi-Lei Zhang Yu Sun Qi-Fei Cong Xue-Chu Zhen Guang-Ying Li
Aug 2026 · Acta Pharmacologica Sinica · 0 citations · 66 references
Medicine

TL;DR

It is demonstrated that S1R is involved in METH-induced behavioral sensitization and that SOMCL-668 could be a potential therapeutic agent for drug addiction.

DOI PubMed Semantic Scholar
View source

Similar papers

Open access Aug 2026

PT320, a GLP-1 receptor agonist, mitigates nucleus accumbens–associated depression- and anxiety-like behaviors in MitoPark mice of Parkinson's disease

By restoring neurotrophic signaling and dopaminergic function, PT320 represents a promising therapeutic strategy for PD-related anxiety and depression by restoring neurotrophic signaling and dopaminergic function in the nucleus accumbens.

Kuan-Yin Tseng, Tung-Tai Kuo, P. Chang et al. · 0 citations
Open access Jul 2026

Role of β‑Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs

The data suggest a role for the β-arrestin2 pathway in psychedelic drug-evoked dendritogenesis of cultured neurons, and this pathway unlikely mediates the hallucinogenic effects of psychedelic drugs but may contribute to neural plasticity changes in certain models.

Aurelija Ippolito, Agnese Tiranti, Shaun Hurley et al. · 0 citations
Jul 2026

Activation of sigma non-opioid intracellular receptor 1 (S1R) receptor inhibits plexin domain containing 2 (Plxdc2) driven microglial inflammation to ameliorate depressive-like behaviours in mice.

Analysis demonstrated that overexpressing Plxdc2 in mPFC microglia activated the JAK2-STAT1 pathway, enhanced NLG, shifting microglia towards a pro-inflammatory phenotype, worsening deficits in synaptic plasticity and induced depressive-like behaviour, which was reversible by the NLG inhibitor tunicamycin.

Jing-ya Wang, Peng Ren, De-Yi Yang et al. · 0 citations
Open access Aug 2026

NDP-MSH rescues LPS-induced neuroinflammation, synaptic deficits, and depressive-like behaviors in mice: involvement of MC1R–cAMP/PKA signaling

MC1R-related signaling in the PFC is highlighted as an important contributor to inflammation-associated depression and NDP-MSH alleviates inflammation-associated depressive-like behaviors in association with melanocortin signaling involving MC1R and downstream cAMP/PKA activation.

Shang-Lan Qu, Xin Peng, Jie-Yu Ji et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.