Dysfunctional Mitochondria in Microglia Drive Cognitive Aging and Neurodegeneration via cGAS-STING.

Guanqin Ma E. Wang Xiaoxu Yan Xiang-Xiong Xu Xiaohong Li Xueling Ma Wan-Hua Yang Jianxiong Zeng Xiaochun Xie

Jul 2026 · Neuroscience Bulletin · 0 citations · 67 references

Medicine

TL;DR

It is demonstrated that dysfunctional mitochondria in microglia act as triggers of metabolic dysregulation, cognitive aging, and neurodegeneration in adult mice, underscoring the significance of tightly regulated metabolism in age-associated neurological diseases.

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