This work identifies transcriptional pathways linking variants in definitive ALS genes to widespread coordinated co-expression activity driven by gene-specific transcriptional programs, and establishes a generalizable framework that is readily applicable across heritable diseases for the identification of disease-relevant molecular pathways and target genes.
These findings underscore the multifactorial nature of ALS across genetic, molecular and metabolic dimensions, identifying potential molecular targets to guide future therapeutic development.
U. Adiga, P. Supriya, S. Adiga et al.· Journal of environmental bio...· 0 citations
A narrative review synthesizes findings from key microarray studies, focusing on dysregulated pathways such as ribosomal function, protein synthesis, and metabolic processes within motor nerves and Schwann cells, and the emerging role of competitive endogenous RNA (ceRNA) networks.
F. Jorge· Brazilian Journal of Biology· 0 citations
RNA-seq data from ALS patients confirmed significant alterations in the expression of host genes of ALS-related circRNAs and hub proteins in ALS-affected CNS tissues, and these findings identify circRNAs as potential key contributors to ALS pathogenesis.
R. Ataei, J. Amini, N. Sanadgol et al.· Neurobiology of Disease· 0 citations
A systems-level view of transcriptomic dysregulation across major neurodegenerative diseases is provided and candidate regulatory interactions and molecular targets for future functional investigation are identified.
Amrit Venkatesan, Prashasti Sinha, J. Basak et al.· bioRxiv· 0 citations
This review examines the common genetic pathways, along with the interactions between genes of major neurodegenerative diseases, with a focus on the key genes, such as APOE, SNCA, MAPT, TARDBP, LRRK2 and HTT.
P. Pattnaik, S. Prusty, Sanghamitra Pati et al.· Gene· 0 citations
It is suggested that integrating disease-state transcriptomics with genetic prioritization can refine PD risk-gene nomination and uncover regulatory programs that may be missed by GWAS alone.
Isabel Alfradique-Dunham, Jessie Sanford, Meng-Han Liu et al.· bioRxiv· 0 citations
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