Open access
Placental Blood‐Flow Velocity Quantification From Diffusion MRI
Zhuang-Jian Yang
D. C. de Oliveira
L. Kerkelä
Marco Palombo
Elizabeth Powell
Christopher S. Parker
D. Cromb
Lisa Story
S. Counsell
K. Payette
J. Hajnal
J. Hutter
Rebecca J. Shipley
Daniel C. Alexander
Paddy J. Slator
Medicine
Abstract
Altered placental capillary blood flow is closely linked to obstetric complications, yet quantifying capillary‐scale blood velocity remains challenging with existing imaging methods. This is partially because capillary networks form disordered microvascular beds at the voxel scale, rather than coherent, directional vessels. Here, we combine Monte Carlo (MC) simulations with machine learning to estimate placental capillary blood velocity directly from diffusion MRI (dMRI) data.