TL;DR
Recent evidence is discussed across Escherichia coli, Citrobacter rodentium, Klebsiella spp.
How defined, host-relevant synthetic communities can facilitate mechanistic determinants for clinical co-occurrence is highlighted, and some of the limitations of current models are outlined while proposing priorities for further research are outlined.
Abstract Enterohemorrhagic Escherichia coli (EHEC) is a major foodborne pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. Increasing evidence indicates that the gut microbiota plays a central role in modulating EHEC pathogenesis through complex metabolic and signaling networks. Beneficial commensa...
Findings showing that the antimicrobial lectin RegIIIβ, together with microbiota-dependent metabolites such as fatty acid-derived cues and polyamines, can unexpectedly facilitate STm colonization support a model in which host defense programs and microbial metabolism are redirected to promote pathogen fitness, revealin...
BACKGROUND Bacteroides fragilis is a dominant member of the human intestinal microbiota and is known for its ecological plasticity and capacity to persist under fluctuating intestinal conditions. Bile salts are abundant host-derived molecules that act not only as antimicrobial agents but also as environmental cues shap...
This review systematically delineates the biological characteristics and metabolic constraints of Faecalibacterium, comprehensively dissecting its cross-feeding mechanisms with pivotal commensals across metabolic complementarity, ecological niche synergy, and multi-species networks.
Critical insights into the development of multidrug resistance in nosocomial pathogens are provided and could enlighten novel drug designs and strategies to combat infections in both clinical and environmental settings.
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