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Genome-wide profiling of histone modifications and transcription factor binding at single-cell resolution by DeChIC-seq

Zhifei Shi Xiyang Chen Yijia Yang Ang Wu Heng Wang Kailiang Chen Chong Li Lina Zou Z. Qu Yuyan Zhao Wen-Jian Gan Shuhui Li Jiayu Chen Wenqiang Liu Jiejun Shi Hong Wang Jiamin Zhang Chenfei Wang Shaorong Gao Xiaoyu Liu
Jul 2026 · Cell Research · Vol 36, pp. 680 - 697 · 1 citation · 113 references
Medicine

TL;DR

DeChIC-seq establishes a conversion-based framework for chromatin profiling that enables mechanistic dissection of TF-driven gene regulation across rare cells, developmental systems, and disease contexts.

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