TL;DR
Seipin is identified as a novel regulator of ferroptosis in the pathogenesis of AD and the potential of the BSCL2-glycine-ferroptosis axis as a therapeutic target is underscored.
Findings in this study highlight the coordinated dysregulation of the FMA axis in AD and provide a computational basis for exploring multi-target therapeutic strategies.
Bioinformatics analysis of hippocampal RNA-sequencing data from AD patients and healthy controls revealed LTF and HAMP as key DEGs related to iron homeostasis, potentially linked to ferroptosis in AD.
Transaldolase 1 (TALDO1) was identified as a key regulator of the impaired PPP in AD and may represent a promising therapeutic target for restoring neuronal metabolic homeostasis and function.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline, amyloid‐β (Aβ) accumulation, oxidative stress, and excitotoxicity. Ferroptosis and N‐methyl‐D‐aspartate (NMDA) receptor activity,may be interconnected in the pathogenesis of Aβ accumulation and associ...
Overall, this review makes a case for integrative, pathway-based therapeutic models, and multiple approaches may facilitate for drug development, biomarker identification and patient management in Alzheimer's disease.
Summary Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with limited therapeutic options. Here, we report that tuberostemonine (Tub), an alkaloid from Stemona tuberosa, exerts neuroprotective effects in AD models. In Aβ1-42-treated PC12 cells, Tub reduced cytotoxicity, apoptosis, and oxidative s...
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