TL;DR
Recent progress in siRNA therapeutics is summarized, with particular emphasis on oncology, and the molecular basis of RNAi, clinical development in cancer, and key barriers limiting broader application are discussed.
A comprehensive overview of the chemical biology and chemical modifications inherent to the design of robust siRNA therapies; the nucleic acid structure–function relationships that dictate the cellular mechanisms underlying siRNA-mediated gene silencing and efficacy; and the current clinical landscape and safety of app...
RNA therapeutics are a quickly developing discipline with enormous promise to improve precision medicine and offer efficient treatment choices for illnesses that are still challenging to treat with traditional medicines.
Peptides offer a versatile approach to enhance siRNA delivery efficiency by functionalizing nanoparticles as surface ligands to enable specific cell targeting, facilitating cellular uptake and promoting endosomal escape.
RNA-based theranostic strategies show promising potential for glioma therapy, however, further optimization of delivery systems, improved safety profiles, and successful clinical translation remain necessary.
The different forms of RNA-based treat-ments, such as messenger RNAs, small interfering RNAs, and circular RNAs, are discussed in this paper along with their significance in gene regulation and the treatment of disease.
This review comprehensively summarized the design principles and functional characteristics of TME-responsive siRNA delivery nanocarriers, with a focus on five major stimuli: pH, hypoxia, enzymes, glutathione (GSH), and reactive oxygen species (ROS).
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
