The CAG hybrid promoter improved not only the expression level, but also the immunogenicity of the fusion protein, and may thus provide a promising strategy for HTNV vaccine research.
A Newcastle disease virus (NDV) vector vaccine candidate expressing the complete envelope (E3–E1) protein of chikungunya virus (CHIKV) successfully develops a novel vaccine candidate that utilizes Newcastle disease virus as a vector to express CHIKV antigens.
Qiu-Yan Zhang, Yang Zhang, Zhe-Rui Zhang et al.· Journal of Virology· 0 citations
Dengue virus rNS3pro immunization drives a robust expansion of multifaceted regulatory-like T-cell phenotypes, identifying the NS3 protease domain as a potential player in DENV immune evasion strategies.
V. Romero-Cruz, A. Ramos-Ligonio, Diana Lizzet Murrieta-León et al.· Acta Tropica· 0 citations
The HEK293T model stably expressing membrane-anchored HIV-1 gp160(ΔCT) model provides a robust platform for benchmarking the targeted recognition and cytotoxic activity of antiviral antibodies, agents, and CAR-T therapies in HIV research.
Jiarui Liu, Yang Gao, Changjun Wang et al.· Sheng wu gong cheng xue bao...· 0 citations
The recombinant virus maintained wild-type-comparable titers while carrying 3606 bp of total foreign sequences, highlighting its dual-site advantage and potential as a multivalent poultry vaccine vector.
It is demonstrated that NTV-ΔF1L-C7L combines high safety with enhanced replication and immunogenicity, supporting its value as a novel vaccine vector and its potential application in controlling the current global monkeypox outbreak.
Jiao Ren, Shi-Yuan Liu, Hang Yuan et al.· Journal of Virology· 0 citations
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