Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated ion channel, ELIC

Abstract

Using molecular dynamics, computational electrophysiology, and single-channel recordings, Arcario et al. identify a cryptic extracellular lateral fenestration in the pentameric ligand-gated ion channel, ELIC, that becomes the dominant cation conduction pathway. Expansion of this pathway is required to reproduce experimental conductance, revealing a revised mechanism of ion permeation in cation-selective pentameric ligand-gated ion channels.