Eugenol regulates ferroptosis through Mfn2/SLC7A11/GPX4 pathway to alleviate glutamate excitotoxicity damage in glaucoma.

Qian Wang Le-Meng Feng Cheng Zhang Weiming Zhu Min He Fangbing Ye Longqing Luo Shi-Qi Qin Zhiqi Xiong Haifa Liu Weitao Song Yumo Xiong

Jul 2026 · Molecular and Cellular Biochemistry · 0 citations · 42 references

Medicine

TL;DR

Eugenol exerts neuroprotective effects in glaucoma excitotoxicity models by suppressing ferroptosis through Mfn2-mediated regulation of mitochondrial-LD homeostasis and the SLC7A11/GSH/GPX4 antioxidant pathway.

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