Siwa spring microbiomes as reservoirs of biosynthetic gene clusters: Unlocking natural product potential

Muhammad A. Ajagbe Shimaa F Ahmed Amged A. Ouf Basma M T Abdoullateef R. Abdallah Rania Siam A. Elbehery

Aug 2026 · World Journal of Microbiology & Biotechnology · Vol 42 · 1 citation · 140 references

Medicine

TL;DR

The integrated bioinformatics pipeline enabled the reconstruction of 37 medium-to-high-quality metagenome-assembled genomes (MAGs), and recovered 147 BGCs mostly from Pseudomonadota, Actinomycetota, and Acidobacteriota phyla, highlighting the Siwa Oasis as a promising reservoir of unexplored biosynthetic potential and a valuable resource for natural product discovery to address global health challenges.

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